Microgel encapsulated nanoparticles for glucose-responsive insulin delivery

An insulin delivery system that self-regulates blood glucose levels has the potential to limit hypoglycemic events and improve glycemic control. Glucose-responsive systems have been developed by coupling oxidase with a stimuli-responsive biomaterial. However, challenge of achieving desirable release kinetics (i.e., within minutes after elevation duration on order weeks) still remains. Here, we develop glucose-responsive using encapsulated glucose-responsive, acetalated-dextran nanoparticles in porous alginate microgels. The respond rapidly changes concentrations while microgels provide them protection stability, allowing for extended release. This reduces sugar diabetic mouse model at rate similar naked responds 3 days administration similarly healthy animal. With 2 doses containing 60 IU/kg each, are able achieve control mice 22 days.